Megan R. Detloff

B.S. in Chemical Engineering, University of Michigan

Thesis Advisor: D. Michele Basso

E-Mail: detloff.1@osu.edu

Research:

My research within the Basso Lab of Functional Recovery, a division of the Spinal Trauma and Repair (STAR) Laboratories, focuses on the changes in sensation and the development of neuropathic pain that occur following spinal cord injury. Currently, my project is looking at potential mechanisms involved in the development of chronic neuropathic pain at segmental spinal as well as supraspinal regions within the pain and sensory pathways. Little is known about the mechanisms that cause neuropathic pain after SCI but the mechanisms have been studied extensively after small lesions to individual peripheral nerves. After peripheral nerve injury which causes neuropathic pain, recent studies found a greater microglial and astrocytic response in the lumbar dorsal horn of the spinal cord where pain signals from the lower limb are processed and relayed to the brain. My project aims to determine whether supraspinal and segmental plasticity mediates changes in sensation resulting from spinal cord injury.

Publications:

Detloff MR, Fisher LC, Longbrake EE, McGaughy V, Popovich PG, Basso DM. Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats. Experimental Neurology. In Press

Detloff MR, Clark L, Fisher LC, Kloos AD, Basso, DM. Early Identificantion of Allodynia after Spinal Cord Injury Prior to Motor Recovery Predicts Chronic. Neuropathic Pain. Manuscript in Preparation.

Detloff MR, Lavik E, Fisher LC, Langer R, Basso DM. Polyethylene Glycol Administration After Moderate Spinal Cord Injury Causes Significant Decreases in Lesion Size and Significantly Greater Locomotor Recovery. J Neurotrauma, In Review.

Kloos AD, Fisher LC, Detloff MR, Hassenzahl DL, and Basso DM. (2005) Stepwise motor and all-or-none sensory recovery is associated with nonlinear sparing after incremental spinal cord injury in rats. Exp Neurol; 191:251-265.

Hall ED, Detloff MR, Johnson K, and Kupina NC. (2004) Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury. J Neurotrauma; 21:9-20.

Detloff MR, Fisher LC, Kloos ZA, Kloos AD, Miller EL, McGaughy V, Popovich PG, and Basso DM. (2004) Neuropathic pain after spinal cord injury and its relationship to glia and ATP receptor upregulation. J Neurotrauma; 21(9):1276.

Kupina NC, Detloff MR, Bobrowski WF, Snyder BJ, and Hall ED. (2003) Cytoskeletal Protein Degradation and Neurodegeneration Evolves Differently in Males and Females Following Experimental Head Injury. Experimental Neurology; 180:55-72.

Kupina NC, Detloff MR, Dutta S, and Hall ED. (2002) Neuroimmunophilin Ligand V-10,367 Is Neuroprotective After 24-h Delayed Administration in a Mouse Model of Diffuse Traumatic Brain Injury. Journal of Cerebral Blood Flow & Metabolism; 22(10):1212-1221.

Presentations at National Meetings:

Detloff MR, Lavik E, Fisher LC, Langer R, Basso DM. Polyethylene glycol administration after moderate spinal cord injury decreases lesion size and improves locomotor recovery. American Physical Therapy Association Combined Sections Meeting (Boston, MA) 2007

Detloff MR, Fisher LC, Longbrake EE, Popovich PG, Basso DM. Remote microglial activation and the production of proinflammatory cytokines predicts the development of neuropathic pain after spinal cord injury. American Physical Therapy Association Combined Sections Meeting (Boston, MA) 2007

Detloff MR, Fisher LC, Song X, Basso DM. SCI-induced neuropathic pain: mechanisms of microglial activation in segmental and supraspinal centers. Program No. 475.7. Society for Neuroscience (Atlanta, GA) 2006

Detloff MR, Lavik E, Fisher LC, Langer R, Basso DM. Polyethylene glycol administration after moderate spinal cord injury decreases lesion size and improves locomotor recovery. Society for Neuroscience (Washington, D.C.) 2005.

Kloos AD, Fisher LC, Hassenzahl DL, Myer D, Detloff MR, Basso DM. Thresholds of motor and sensory recovery after incremental spinal cord injury in rats. American Physical Therapy Association Combined Sections Meeting (Nashville, TN) 2004.

Kloos AD, Fisher LC, Hassenzahl DL, Myer D, Detloff MR, Basso DM. Thresholds of motor and sensory recovery after incremental spinal cord injury in rats. Tenth Annual Kentucky Spinal Cord and Head Injury Research Symposium (Lexington, KY) 2004.

Detloff MR, Fisher LC, Kloos ZA, Miller EL, Basso DM. Neuropathic pain after spinal cord injury appears to be associated with upregulation of ATP receptor P2X4. Tenth Annual Kentucky Spinal Cord and Head Injury Research Symposium (Lexington, KY) 2004.

Detloff MR, Fisher LC, Kloos ZA, Kloos AD, Miller EL, McGaughy V, Popovich PG, Basso DM. Neuropathic pain after spinal cord injury and its relationship to glia and ATP receptor upregulation. Program No. 458.5 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

Hall ED, Detloff MR, Gibson TR, Kupina NC. Peroxynitrite-mediated protein nitration and lipid peroxidation in mouse models of diffuse and focal traumatic brain injury. Annual Meeting for the National Neurotrauma Society. (Biloxi, MS) 2003.

Kloos AD, Fisher LC, Hassenzahl DL, Myer D, Detloff MR, Basso DM. Thresholds of motor and sensory recovery after incremental spinal cord injury in rats and the critical descending systems that support them. Program No. 498.4. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

Kupina NC, Detloff MR, Bobrowski WF, Snyder BJ and Hall ED. Cytoskeletal Protein Degradation and Neurodegeneration Evolves Differently in Males and Females Following Experimental Head Injury. First Joint Symposium of the National and International Neurotrauma Societies, (Tampa, FL) 2002.

Hall ED, Detloff MR, Dutta S and Kupina NC: Neuroprotective Effect of the Neuroimmunophilin V-10,367 following 24-hr Delayed Administration in a Mouse Model of Diffuse Traumatic Brain Injury. Presentation. National Society for Neuroscience Satellite Symposium (San Diego, CA) 2001.

Kupina NC, Detloff MR, Dutta S, Hall ED. Neuroprotective effect of the neuroimmunophilin V-10,367 following 24-h delayed administration in a mouse model of traumatic brain injury. Annual Meeting of the Society for Neuroscience - Michigan Chapter, (Michigan State University, Lansing, MI) 2001.

Kupina NC, Detloff MR, Dutta S, Hall ED. Neuroprotective effect of the neuroimmunophilin V-10,367 following 24-h delayed administration in a mouse model of traumatic brain injury. Annual Meeting for the National Society for Neuroscience, (San Diego, CA) 2001.