David L. Schonberg

B.A. in Zoology, Miami University
M.PH. in Public Health, The Ohio State University

Thesis Advisor: Dana M. McTigue

E-Mail: schonberg.2@osu.edu

Research:

My research focuses on how inflammation can lead to new oligodendrocyte formation following spinal cord injury. To uncover the mechanism or factors necessary to induce oligogenesis after injury I will begin with utilizing simplified models such as in vivio microinjections followed by supporting my hypotheses using knockout mice and/or siRNA and in vitro systems. Since last year I have shown that there is a particular inflammatory paradigm that results in new oligogenesis and now I am beginning to study specific elements involved in this process which range from cytokines and growth factors to transition metals.

Publications:

Schonberg, D.L., Popovich, P.G., and McTigue, D.M. (2007) Oligodendrocyte genesis is differentially influenced by Toll-like receptor (TLR2) and TLR4 mediated intraspinal macrophage activation. J Neuropath and Exp Neurol. 66(12):1124-1135.

Fischer AJ, Skorupa D, Schonberg DL, and Walton NA (2006) Characterization of glucagon-expressing neurons in the chicken retina. J Comp Neurol. 496:479-94.

Presentations at National Meetings:

Schonberg, D.L., Popovich, P.G., and McTigue, D.M. (2007) Distinct intraspinal macrophage activation protocols differentially influence oligodendrocyte genesis. Abstract for poster presentation, National Neurotrauma Symposium, Kansas City, MO.