David L. Schonberg

B.A. in Zoology, Miami University
M.PH. in Public Health, The Ohio State University

Thesis Advisor:  Dana M. McTigue

E-Mail:  schonberg.2@osu.edu

Research:

My research focuses on how inflammation can lead to new oligodendrocyte formation following spinal cord injury.  To uncover the mechanism or factors necessary to induce oligogenesis after injury I will begin with utilizing simplified models such as in vivio microinjections followed by supporting my hypotheses using knockout mice and/or siRNA and in vitro systems.  Since last year I have shown that there is a particular inflammatory paradigm that results in new oligogenesis and now I am beginning to study specific elements involved in this process which range from cytokines and growth factors to transition metals.

Awards:

• 2007    National Neurotrauma Symposium Travel Grant, National Neurotrauma Society
• 2009    Alumni Grant for Graduate Research and Scholarship, OSU

Publications:

Gensel JC, Almad AA, Alexander JK, Schonberg DL, Tripathi RB (2008) Does chronic remyelination occur for all spared axons after spinal cord injury in mouse? J Neurosci. 28(34):8385-6.

Schonberg DL, Popovich PG, and McTigue DM (2007) Oligodendrocyte genesis is differentially influenced by Toll-like receptor (TLR2) and TLR4 mediated intraspinal macrophage activation.  J Neuropath and Exp Neurol. 66(12):1124-1135.

Fischer AJ, Skorupa D, Schonberg DL, and Walton NA (2006) Characterization of glucagon-expressing neurons in the chicken retina.  J Comp Neurol. 496:479-94.

Presentations at National Meetings:

Schonberg DL and McTigue DM. Iron is Essential for Oligodendrocyte Genesis following Intraspinal Macrophage Activation. Abstract for poster presentation, American Society of Neurochemistry, Charleston, SC., 2009

Schonberg DL and McTigue DM. Iron is Essential for Oligodendrocyte Genesis following Intraspinal Macrophage Activation. Abstract for poster presentation, Society for Neuroscience, Washington, DC., 2008

Schonberg DL, Popovich PG, and McTigue DM. Distinct intraspinal macrophage activation protocols differentially influence oligodendrocyte genesis. Abstract for poster presentation, National Neurotrauma Symposium, Kansas City, MO 2007.

Schonberg DL, Popovich PG, and McTigue DM. Oligodendrocyte genesis is differentially influenced by Toll-like receptor (TLR2) and TLR4 mediated intraspinal macrophage activation. Abstract for poster presentation, Society for Neuroscience, San Diego, CA 2007.