Anthony Alfredo

Anthony Alfredo

Anthony Alfredo

Advisor: Dana McTigue
He/Him/His

alfredo.2@buckeyemail.osu.edu

(614) 688-5425

670 Biomedical Research Tower
460 W. 12th Avenue
Columbus, OH 43210

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Areas of Expertise

  • Neurotrauma, Neurological Disorders and Gene/Clinical Therapies
  • Molecular and Cellular Neuroscience

Education

  • BS in Neuroscience (2016), The Ohio State University

Research

My research focuses on attenuating metabolic dysfunction after traumatic spinal cord injury (SCI). Specifically, our lab has previously shown that SCI leads to chronic liver pathology and development of metabolic syndrome. These comorbidities are common in the SCI patient population and may contribute to their reduced quality of life and prognosis. The goal of my research is to begin understanding the mechanisms that cause post-SCI liver dysfunction and metabolic syndrome and assess therapeutic strategies aimed to prevent these conditions.

Publications

Goodus MT, Carson KE, Sauerbeck AD, Dey P, Alfredo AN, Popovich PG, Bruno RS, McTigue DM. (2021) Liver inflammation at the time of spinal cord injury enhances intraspinal pathology, liver injury, metabolic syndrome and locomotor deficits. Exp Neurol. 342:113725.

Sauerbeck AD, Goldstein EZ, Alfredo AN, Norenberg M, Marcillo A, McTigue DM. (2021) Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss. Sci Rep. 11(1):11720.

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