Nicole Pukos

Advisor: Dana McTigue
Graduate Student


My research focuses on extracellular and intracellular regulation of oligodendrocyte precursor cells (OPCs) after spinal cord injury. We believe remyelination due to OPC proliferation and differentiation is regulated by axonal glutamate. I am also interested in a more translational approach that focuses on the role of glutamate after SCI. Previous work has shown glutamate levels are elevated after injury, creating an excitotoxic environment that contributes to secondary injury. Our lab has collaborations with multiple labs on and off campus in the hopes on finding a treatment to improve functional recovery after SCI. In particular, I am testing a drug that reduces glutamate levels after injury, and using a novel drug delivery approach that should specifically target the spinal cord after injury.

Areas of Expertise
  • Neurotrauma, Neurological Disorders, and Gene Therapy
  • Molecular and Cellular Neuroscience