Jason Siu

Medical Scientist Training Program Student; Advisor: Lei Cao
Graduate Student

 

Research:

In the Cao lab, we are mainly interested in environmental influence on the brain. Our research focuses on how the brain plays a key role in responding to various environmental stress and subsequently modulating behavior, peripheral cancers, metabolism, and adipose tissue remodeling.

I have a variety of interests, with several projects focusing on the following themes:

  • Genetic models of anxiety and depression
  • The role of neurotrophins in adult neurogenesis and neurodegenerative disease
  • Identification of brain mediators of eustress vs. distress
  • Understanding the effect of overtraining syndrome on the brain of adolescents/athletes
  • Improving viral vectors and delivery for applications in gene therapy
  • Delineation of the neural circuitry along the HPA/HSA axis involved in the anti-tumor effects of environmental enrichment.

Awards:

2017 - Travel Award, Neuroscience
 
2017 - Outstanding Poster Presentation, IGP Symposium
 
2017 - Meritorious Abstract Travel Award, ASGCT
 

2017 - Edgar J. Ray Travel Award, Council of Graduate Students

2016 - Travel Award, Neuroscience

2015 - Ray Travel Award, OSU

Publications:

Siu, J.J., Queen, N.J., Liu, X.L., Huang, W., Mcmurphy, T., and Cao, L. (2017). Molecular Therapy of Melanocortin-4-Recptor Obesity by an Autoregulatory BDNF Vector. Molecular Therapy, 7:83-95.
 
Siu, J.J., Queen, N.J., Huang, W., Yin, F.Q., Liu, X.L., McTigue, D.M., and Cao, L. (2017). Improved Gene Delivery to Adult Mouse Spinal Cord Through the Use of Hybrid Adeno-Associated Viral Serotypes. Gene Therapy, 24(6): 361-69.
 
Xiao, R., Bergin, S.M., Huang, W., Liu, X.L., Judd, R., Widstrom, K., Siu, J.J., Caligiuri, M.A., and Cao, L. (2017). Environmental enrichment regulates thymocyte development via hypothalamic BDNF and ameliorates experimental autoimmune encephalitis. Manuscript in revision.
 
McMurphy, T., Huang, W., Liu, X.L., Widstrom, K., Xiao, R., Queen, N.J., Siu, J.J., and Cao, L. Environmental activation of a hypothalamic-adipocyte axis promotes healthy aging. Manuscript in revision. 2017.
 

Foglesong, G.D., Huang, W., Liu, X., Slater, A.M., Siu, J., Yildiz, V., Salton, S.R., and Cao, L. Role of Hypothalamic VGF in Energy Balance and Metabolic Adaption to Environmental Enrichment in Mice. Endocrinology. January 5, 2016.

Kim SH, Joshi K, Ezhilarasan R, Myers TR, Siu J, Gu C, Nakano-Okuno M, Taylor D, Minata M, Sulman EP, Lee J, Bhat KP, Salcini AE, Nakano I. (2015) EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner. Stem Cell Reports. 4(2):226-38.

Presentations:

Siu, J.J., Queen, N.J., Liu, X.L., Huang, W., McMurphy, T.B., and Cao, L. May 2017. Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector. 31st ASGCT 20th Annual Meeting. Marriott Wardman Park Hotel. Washington, DC.
 
Siu, J.J., Queen, N.J., Liu, X.L., Huang, W., Mcmurphy, T., and Cao, L. May 2017. Molecular Therapy of Melanocortin-4-Recptor Obesity by an Autoregulatory BDNF Vector. 5th Annual Department of Internal
Medicine (DOIM) Clinician Scientist Trainee Research Day. The Ohio State University. Columbus, OH.
 
Siu, J.J., Queen, N.J., Liu, X.L., Huang, W., Mcmurphy, T., and Cao, L. May 2017. Molecular Therapy of Melanocortin-4-Recptor Obesity by an Autoregulatory BDNF Vector. Annual OSU Life Sciences Interdisciplinary Graduate Programs (IGP) Symposium. The Ohio State University. Columbus, OH.
 
Siu, J.J., Queen, N.J., Liu, X.L., Huang, W., Mcmurphy, T., and Cao, L. April 2017. Molecular Therapy of Melanocortin-4-Recptor Obesity by an Autoregulatory BDNF Vector. 16th Annual OSUWMC Trainee Research Day. 2017.
 
Siu, J.J., Queen, N.J., Liu, X.L., Huang, W., McMurphy, T.B., and Cao, L. March 2017. Brain-Adipocyte Axis Activation by Gene Transfer Treats Melanocortin-4-Receptor Obesity. 31st Edward F. Hayes Graduate Research Forum. The Ohio State University. Columbus, OH.
 
Siu, J.J., Queen, N.J., Liu, X.L., Huang, W., and Cao, L. July 2016. Brain-Adipocyte Axis Activation by Gene Transfer Treats Melanocortin-4-Receptor Obesity. 31st Annual 2016 National MD/PhD Student Conference. Keystone Conference Center. Keystone, CO.
 
Siu, J.J., Liu, X.L., Huang, W., and Cao, L. April 2016. Brain-Adipocyte Axis Activation by Gene Transfer Treats Melanocortin-4-Receptor Obesity. 15th Annual OSUWMC Trainee Research Day. The Ohio State University. Columbus, OH.

 

Areas of Expertise
  • Molecular and Cellular Neuroscience
  • Behavioral Neuroscience
  • Neurotrauma, Neurological Disorders and Gene Therapy
  • Stress and Neuroimmunology
Education
  • BS in Biochemistry and Cell Biology, Rice University
  • BS in Economics, Rice University
 

Picture for siu.12

Phone:
(614) 247-4063
940 Biomedical Research Tower
460 W. 12th Avenue
Columbus, OH 43210