Lars Nelson

Advisor: Kathryn Lenz
Graduate Student

 

Research:

I am interested in the immune system influences early brain development. Previous research has shown that microglia can regulate cellular proliferation in the ventricular zones during development by releasing diffusible factors, and through phagocytizing progenitor cells. Additionally, previous work has shown that there is a sex difference in neonatal hippocampal neurogenesis with males having more neurogenesis than females. I am researching how microglia regulate cellular proliferation and the progenitor pool size in the neonatal hippocampus, and whether microglia do so in a sex‐dependent manner. My research will provide insight as to how immune disturbances during development may contribute to psychiatric disorders such as autism.

Publications:

Nelson, L.H., Warden, S., Lenz, K.M., 2017. Sex differences in microglial phagocytosis in the neonatal hippocampus. Brain, Behavior, and Immunity 64, 11–22. doi:10.1016/j.bbi.2017.03.010
 
Nelson LH, Lenz KM. The immune system as a novel regulator of sex differences in brain and behavioral development. J Neurosci Res. 2017 Jan 2;95(1-2):447-461. PubMed PMID: 27870450.
 
Nelson LH, Lenz KM. Microglia depletion in early life programs persistent changes in social, mood-related, and locomotor behavior in male and female rats. Behav Brain Res. 2017 Jan 1;316:279-293. PubMed PMID: 27613230.
 
Presentations:
 
Nelson LH, Peketi P, & Lenz KM (2017). Sex differences in microglial phagocytosis and support of neurogenesis in the neonatal hippocampus. Society for Behavioral Neuroendocrinology, Long Beach, California.
 
Nelson LH, Peketi P, & Lenz KM (2017). Sex differences in microglial phagocytosis and support of neurogenesis in the neonatal hippocampus. OSU Life Sciences Interdisciplinary Graduate Program Symposium, OSU, Columbus, OH.
 
Nelson LH, Warden S, & Lenz KM (2017). Early life depletion of microglia programs lifelong mood-related behavior and brain development. Hayes Research Forum, OSU, Columbus, OH.
 
Nelson LH, & Lenz KM (2017). Neonatal depletion of microglia programs lifelong mood-related behavior and brain development. IBMR Research Day, OSU, Columbus. OH
 
Nelson LH, Warden S, & Lenz KM (2016). Early life depletion of microglia programs lifelong mood-related behavior and brain development. Society for Neuroscience, San Diego, CA.

 

Areas of Expertise
  • Behavioral Neuroscience
  • Stress and Neuroimmunology
  • Neurotrauma, Neurological Disorders and Gene Therapy
Education
  • BS in Biology, American University
  • BS in Recording Arts, University of Colorado Denver
 

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Phone:
(614) 292-6573
225 Psychology Building
1835 Neil Avenue
Columbus, OH 43210