Shane O'Neil

Shane O'Neil

Shane O'Neil

Advisor: Jonathan Godbout

(614) 366-3496

247 Institute for Behavioral Medicine Research
460 Medical Center Drive
Columbus, OH 43210

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Areas of Expertise

  • Stress and Neuroimmunology


  • BS in Neuroscience (2016), University of Rochester
  • BA in Chemistry (2016), University of Rochester
  • MS in Neuroscience (2019), The Ohio State University


My research interests focus on the age-associated dysregulation between the immune system and the central nervous system. I am particularly interested in the impaired signaling between microglia and astrocytes in the aged brain.


2021 - Honorable Mention Health Sciences Oral Presentation, The Ohio State University Edward F. Hayes Graduate Research Forum
2020 - Excellence in Undergraduate Research Mentoring Award, The Ohio State University
2019 - Outstanding Poster Award, The Ohio State University IGP Symposium
2018 - Psychoneuroimmunology Research Society Trainee Scholar Award, PNIRS
2018 - Training in Oral and Craniofacial Sciences Pre-doctoral Fellowship (T32-DE014320)
2016 - Dean's Distinguished University Fellowship, The Ohio State University Graduate School (3-year award)


Witcher KG, Bray CE, Chunchai T, Zhao F, O’Neil SM, Gordillo A, Campbell WA, McKim DB, Liu X, Dziabis  JE, Quan N, Eiferman DS, Fischer A, Kokiko-Cochran ON, Askwith C, Godbout JG. (2021) Traumatic brain injury  causes chronic cortical inflammation and neuronal dysfunction mediated by microglia. J Neurosci.
Kumar JE, Tapp ZM, Witcher KG, Atluri RR, Velasquez J, O’Neil SM., Dziabis J, Bray C, Sheridan JF, Godbout  JP, Kokiko-Cochran ON. (2020) Sleep disruption exacerbates and prolongs the inflammatory response to traumatic  brain injury. J Neurotrauma.
DiSabato DJ, Nemeth DP, Liu X, Witcher KG, O'Neil SM, Oliver B, Bray CE, Sheridan JF, Godbout JP, Quan N. (2020) Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic  social stress. Mol Psychiatry.
O'Neil SM, Witcher KG, McKim DB, Godbout JP (2018) Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge. Acta Neuropathol Commun. 2018 Nov 26;6(1):129. doi: 10.1186/s40478-018-0636-8.

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