Chloe Page

Advisor: Laurence Coutellier
Graduate Student

 

Research:

The prefrontal cortex provides top-down control over limbic system activity and integrates perceptions, memories, and emotions to guide behavior. These functions depend in part on a homeostatic balance between glutamatergic and GABAergic neurotransmission. Psychological stress has been shown to disrupt this balance, contributing to the development of psychiatric disorders such as anxiety and depression. Specifically, chronic stress induces hypoactivity of the prefrontal cortex in a sex-dependent manner. Inhibitory parvalbumin interneurons are likely contributors to hypofrontality as these cells dynamically regulate activity and plasticity according to development and experience. My research focuses on how chronic stress perturbs parvalbumin cells at a molecular and network level, and takes lessons from GABAergic system maturation and critical periods of plasticity to investigate therapeutic avenues aimed at restoring PFC functioning. I use behavioral models along with molecular and opto/chemogenetic techniques to study this interaction between stress, excitatory/inhibitory balance, and affective disorders.

Publications:

Page CE, Alexander J, Shepard R, Coutellier L. (2018) Npas4 deficiency interacts with adolescent stress to disrupt prefrontal GABAergic maturation and adult cognitive flexibility. Genes, Brain and Behavior, e12459. 

Shepard R, Page CE, Coutellier L. (2016) Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders. Neuroscience, 332: 1-12.

Hansen K, Sakamoto K, Aten S, Snider KH, Loeser J, Hesse AM, Page CE, Pelz C, Arthur JSC, Impey S, Obrietan K. (2016) Targeted deletion of mir-132/-212 impairs memory and alters the hippocampal transcriptome. Learning & Memory, 23: 61-71.

Presentations:

Page CE, Alexander J, Shepard R, Coutellier L. Npas4 deficient mice lack homeostatic resilience against mild stress in adolescence and show impaired cognitive flexibility in adulthood. Poster session at: Society for Neuroscience, 2017 November 11-15, Washington DC.

Page CE, Alexander J, Shepard R, Coutellier L. Npas4 deficient mice lack homeostatic resilience against mild stress in adolescence and show impaired cognitive flexibility in adulthood. Poster session at: Cell Symposia: Big Questions in Neuroscience, 2017 November 9-10, Arlington VA. 

Page CE, Alexander J, Coutellier L. Npas4-deficient mice lack homeostatic resilience against mild stress in adolescence and show impaired cognitive flexibility in adulthood. Oral presentation at: Interdisciplinary Graduate Programs Life Sciences Symposium; 2017 May 23; Columbus, OH.

Page CE, Alexander J, Coutellier L. Npas4 deficiency interacts with adolescent stress to impair extradimensional set shifting in adulthood. Poster session at: Institute for Behavioral Medicine Research, Research Day; 2017 April 5; Columbus, OH.

Page CE, Alexander J, Coutellier L. Npas4-deficient mice lack cellular resilience against mild stress in adolescence and show impaired cognitive flexibility in adulthood. Presentation at: 11th International Regional Stress and Behavior Neuroscience and Biopsychiatry Conference (North America); 2017 June 22-24; Miami Beach, FL.

Areas of Expertise
  • Behavioral Neuroscience
  • Molecular and Cellular Neuroscience
Education
  • BA in Psychology, Kalamazoo College
 

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