Isabella Palazzo

Isabella Palazzo

Isabella Palazzo

Advisor: Andy Fischer

palazzo.7@buckeyemail.osu.edu

(614) 292-1226

3140 Graves Hall
333 W. 10th Avenue
Columbus, OH 43210

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Areas of Expertise

  • Molecular and Cellular Neuroscience

Education

  • BS in Biology (2016), The Ohio State University
  • MS in Neuroscience (2017), The Ohio State University

Research

My research interests are currently focused on understanding mechanisms that mediate retinal regeneration. Currently, my work in the Fischer lab focuses on retinal regeneration via Muller glia, the primary glial cell of the retina. Muller glia have the capacity to dedifferentiate and proliferate as progenitor cells prior to giving rise to new neuron populations. More specifically, my interests lie in understanding the complex network of cell signaling pathways that are involved in Muller glia cell reprogramming and neurogenesis after retinal disease or injury.

Awards

2021 - First Place Oral Presentation, The Ohio State University IGP Symposium

2021 - Presidential Fellowship, The Ohio State University Graduate School

2019 - Training Program in Neuroimmunology T32 Fellow (2-year award)

2019 - Second Place Oral Presentation, The Ohio State University IGP Symposium

2018 - Young Investigator Student Fellowship Award for Female Scholars in Vision Research, Prevent Blindness Foundation

2018 - Joseph M. and Eula C. Lawrence Travel Grant, ARVO Foundation/Retina Research Foundation

2017 - University Fellowship, The Ohio State University Graduate School

2016 - Travel Grant for Explorations in Neuroscience Camp volunteer, The Ohio State University Department of Neuroscience

Publications

Campbell, W.A., Fritsch, M., Palazzo, I., Hoang, T., Blackshaw, S., Fischer, A.J. (2021) Midkine is neuroprotective and influences glial reactivity and the formation Müller gliaderived progenitor cells in chick and mouse retinas. Glia. 69(6):1515-1539.

Hoang, T., Wang, J., Boyd, P., Wang, F., Santiago, C., Jiang, L., Lahne, M., Todd, L.J., Saez, C., Yoo, S., Keuthan, C., Palazzo, I., Squires, N., Campbell, W.A., Jia, M., Rajaii, F., Payail, T., Wang, G., Ash, J., Fischer, A.J., Hyde, D.R., Qian, J., Blackshaw, S. (2020) Gene regulatory networks controlling vertebral retinal regeneration. Science (370:6519).

Palazzo, I., Deistler, K., Hoang, T.V., Blackshaw, S., Fischer, A.J. (2020) NF-kB signaling regulated the formation of proliferating Müller glia-derived progenitor cells in the avian retina. Development 147(10).

Todd, L.*, Palazzo I.*, Suarez L.,Liu X., Volkov L., Hoang T.V., Warren Campbell W.A., Blackshaw S., Quan N., Fischer A.J. (2019) Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina. Journal Neuroinflammation. 118(16). PMID: 31170999. (* indicates co-first author)

Todd, L., Palazzo, I., Squires, N., Mendonca, N. & Fischer A.J. (2017). BMP- and TGFB- signaling regulate the formation of Muller glia-derived progenitor cells in the avian retina. Glia, 65(10): 1640-55.

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