Luke Russell

Advisor: Balveen Kaur
Alumni

 

Research:

The goal of my research is to improve the current standard of care for glioblastoma brain tumor patients using oncolytic viral vectors. My role in the lab is to explore better ways to target tumor cells that may be refractive to chemo and radiation therapies, and to improve the efficacy of our HSV-1 oncolytic viral vectors for terminating glioblastoma through viral genome manipulations. I am currently exploring the PTEN pathway which is known to be dysregulated in ~70% of high grade gliomas, and am targeting that pathway as a method for improving tumor cell killing.

Awards:

2017 - Trainee Research Day Travel Award, OSUMC

2016 - Pelotonia Graduate Fellowship, Pelotonia

Publications:

Russell L, Bolyard C, Banasavadi-Siddegowda Y, Weiss A, Zhang J, Shakya R, Powell K, Kaur B. Sex as a Biological Variable in Response to Temozolomide. Neuro Oncol. 2017 Jun 1;19(6):873-874.
 

Banasavadi-Siddegowda YK, Russell L, Frair E, Karkhanis VA, Relation T, Yoo JY, Zhang J, Sif S, Imitola J, Baiocchi R, Kaur B. (2017) PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells. Oncogene. 36(2):263-274.

Meisen WH, Wohleb ES, Jaime-Ramirez AC, Bolyard C, Yoo JY, Russell L, Hardcastle J, Dubin S, Muili K, Yu J, Caligiuri M, Godbout J, Kaur B. (2015) The Impact of Macrophage- and Microglia-Secreted TNFα on Oncolytic HSV-1 Therapy in the Glioblastoma Tumor Microenvironment. Clin Cancer Res. 21(14):3274-85. 

Jacobsen K, Russell L, Kaur B, Friedman A. (2015) Effects of CCN1 and Macrophage Content on Glioma Virotherapy: A Mathematical Model. Bull Math Biol. 77(6):984-1012. 

Thorne AH, Meisen WH, Russell L, Yoo JY, Bolyard CM, Lathia JD, Rich J, Puduvalli VK, Mao H, Yu J, Caligiuri MA, Tridandapani S, Kaur B. (2014) Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance. Mol Ther. 22(9):1678-87

Presentations:

A novel oncolytic Herpes Simplex Virus 1 expressing PTEN-L for brain tumor therapy. Allen Yates Memorial Speaker Series, OSUWMC Trainee Research Day, April 13, 2017. Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH.
 
Luke Russell, Alex Sprague, Chelsea Bolyard, Yeshavanth Banasavadi-Siddegowda, Cristina Jaime-Ramirez, Ji Young Yoo, Gina Sizemore, Raleigh Kladney, Pin-Yi Wang, Timothy Cripe, Michael Ostrowski, Norman Lehman, Balveen Kaur. A novel oncolytic Herpes Simplex Virus 1 expressing PTEN-L for brain tumor therapy. OSUWMC Trainee Research Day. April 13, 2017. Biological Research Tower, Ohio State University, Columbus, OH.
 
Luke Russell, Alex Sprague, Chelsea Bolyard, Yeshavanth Banasavadi-Siddegowda, Cristina Jaime-Ramirez, Ji Young Yoo, Gina Sizemore, Pin-Yi Wang, Timothy Cripe, Michael Ostrowski, Norman Lehman, Balveen Kaur. Oncolytic, PTEN-L expressing herpes simplex virus RAPTOR affects PD-L1 expression for brain tumor therapy. AACR (American Association for Cancer Research) annual meeting 2017. April 1-5, 2017. DC Convention Center, Washington, DC.
 
Oncolytic and immune effects of RAPTOR: a novel oncolytic Herpes Simplex Virus 1 expressing PTEN-L for brain tumor therapy. Hayes Graduate Forum, March 3, 2017. Ohio Union, Ohio State University, Columbus, OH.
 
A novel oncolytic Herpes Simplex Virus 1 expressing PTEN-L for brain tumor therapy. 20th TRCCC Annual Meeting. February 15-17, 2017. Seven Springs Resort, Seven Springs, PA.
 
Luke Russell, Alex Sprague, Chelsea Bolyard, Yeshavanth Banasavadi-Siddegowda, Cristina Jaime-Ramirez, Pin-Yi Wang, Timothy Cripe, Balveen Kaur. A novel oncolytic Herpes Simplex Virus 1 expressing PTEN-L for brain tumor therapy. 20th TRCCC Annual Meeting. February 15-17, 2017. Seven Springs Resort, Seven Springs, PA.
 
Luke Russell, Alex Sprague, Chelsea Bolyard, Yeshavanth Banasavadi-Siddegowda, Cristina Jaime-Ramirez, Martin Benej, Pin-Yi Wang, Timothy Cripe, Nickolas Denko, Balveen Kaur. Characterization of the oncolytic and immune effects of RAPTOR: a novel oncolytic Herpes Simplex Virus 1 expressing PTEN-L for brain tumor therapy. 10th International Meeting on Replicating Oncolytic Viral Therapeutics. October 1-4, 2016. Fairmont Waterfront, Vancouver, British Columbia, Canada.
Areas of Expertise
  • Neuro-Oncology
Education
  • BS in Microbiology, University of Wisconsin-Madison
 

Picture for russell.821

Phone:
(614) 292-6109
860 Biomedical Research Tower
460 W 12th Ave
Columbus, OH 43210