Levi Todd

Advisor: Andrew Fischer
Alumni

 

Research:
 
Müller glia can be stimulated to de-differentiate and become proliferating progenitor cells that regenerate neurons in the retina. The signaling pathways that regulate the formation of proliferating Müller glia-derived progenitor cells (MGPCs) are beginning to be revealed. I am investigating how various cell signaling pathways impact the formation of MGPCs in the avian and mouse retina. I am particularly interested in how to increase the neurogenic potential of MGPCs with the aim of bolstering retinal regeneration in the higher vertebrate.
 
Awards:
 
2014 - Travel Grant, ARVO
 
Publications:
 
Todd, L., Suarez, L., Volkov, L & Fischer A.J. Microglia are neuroprotective in response to excitotoxic damage in the mouse retina. In Preparation
 
Todd, L, Suarez, L, Quinn, C & Fischer A.J. (2017). Retinoic Acid-signaling regulates the proliferative and neurogenic capacity of Muller glia-derived progenitor cells in the avian retina. Epub ahead of print.
 
Gombash, S., Cowley, C., Fitzgerald, J., Lepak, C., Neides, M., Hook, K., Todd, L., Wang, Guo-Du., Mueller, C., Kaspar, B., Bielefeld, E., Fischer, A., Wood, J & Foust, K. (2017). Systemic Gene Delivery Transduces the Enteric Nervous System of Guinea Pigs and Cynomolgus Macaques. Gene Therapy, 24(10): 640-48.
 
Todd, L., Palazzo, I., Squires, N., Mendonca, N. & Fischer A.J. (2017). BMP- and TGFB- signaling regulate the formation of Muller glia-derived progenitor cells in the avian retina. Glia, 65(10): 1640-55.
 
Todd, L. & Zelinka, C. (2017). Valproic Acid for a treatment of Retinitis Pigmentosa: Reasons for Optimism and Caution. Journal of Neuroscience 37 (21): 5215-5217
 
Todd, L., Squires, N., Suarez, L. & Fischer A.J. (2016). Jak/Stat signaling regulates the proliferation and neurogenic potential of Muller glia-derived progenitor cells in the avian retina. Scientific Reports 6:35703. PMID: 27759082
 
Zelinka, C.P. Volkov, L.I., Goodman, Z.A. Todd, L., Palazzo, I, Bishop, W.A. & Fischer A.J. (2016). mTor-signaling is required for the formation of proliferating Muller glia-derived progenitor cells in the chick retina. Development 143(11):1859-73. PMID: 27068108
 
Todd L, Fischer AJ. (2015) Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retina. Development. 142(15):2610-22. 

Todd L, Suarez L, Squires N, Zelinka CP, Gribbins K, Fischer AJ. (2015) Comparative analysis of glucagonergic cells, glia, and the circumferential marginal zone in the reptilian retina. J Comp Neurol. doi: 10.1002/cne.23823. [Epub ahead of print]

Fischer AJ, Zelinka C, Gallina D, Scott MA, Todd L. (2014) Reactive microglia and macrophage facilitate the formation of Müller glia-derived retinal progenitors. Glia. 62(10):1608-28. 

Gallina D, Todd L, Fischer AJ. (2014) A comparative analysis of Müller glia-mediated regeneration in the vertebrate retina. Exp Eye Res. 123:121-30.
 
Presentations:
 
Todd, L., Suarez, L., Quinn, C. & Fischer, A.J. (2017). Retinoic acid signaling promotes proliferation and neuronal differentiation from Muller glia-derived progenitor cells in the avian retina. ARVO Retinal Glia Paper Session.
 
Todd, L., Mendonca, N., Palazzo, I., Squires, N. & Fischer, A.J. (2016). TGF-beta signaling suppresses the formation of Muller glia derived progenitor cells in the avian retina. Society for Neuroscience. 208.23
 
Todd, L., Palazzo, I., Squires, N. & Fischer, A.J. (2016). BMP/SMAD-signaling is necessary for the formation of proliferating Muller glia-derived progenitors. ARVO. 1132/B0351

 

Areas of Expertise
  • Molecular and Cellular Neuroscience
Education
  • BS in Neuroscience, University of Nebraska-Omaha
 

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Phone:
(614) 292-1226
3140 Graves Hall
333 W. 10th Avenue
Columbus, OH 43210