I am currently studying the effects of peripheral tumor development on neuroinflammation and affective behavior. Estimates suggest that women diagnosed with breast cancer are 25-33% more likely to develop a mood disorder relative to the general population, with some studies demonstrating that as many as 50% will develop a mood disorder that presents depressive or anxious symptoms. To date a definitive cause of cancer related affective disorders has not been conclusively established. However, recent studies have suggested a link between peripheral tumor induced neuroinflammation and affective behavior.
2017 - Explorations in Neuroscience High School Camp Travel Award, Ohio State Neuroscience
2017 - PsychoNeuroImmunology Research Society Trainee Scholar Award, PsychoNeuroImmunology Research Society
Borniger JC*, Walker II WH*, Surbhi, Zhang N, Zalenski AA, Muscarella SL, Hollyfield JL, Fitzgerald JA, Cisse YM, Gaudier-Diaz MM, Magalang UJ, Lustberg MB, Hinzey AH, Nelson RJ, & DeVries AC. (2017). Metabolic and Sleep Abnormalities Arise Independent of Tumor-Derived Inflammation in Mice with Non-Metastatic Breast Cancer. In review
*authors contributed equally to the work
Walker II, W.H. , Borniger, J.C., Gahlot, S., Zalenski, A.A., Muscarella, S.L., Fitzgerald, J.A., Zhang, N., Gaudier Diaz, M.M., and DeVries, A.C. Mammary Tumors Induce Neuroinflammation but not Behavioral Deficits in Balb/C Mice. PsychoNeuroImmunology Research Society Annual Meeting, Galveston TX, data blitz and poster, June 2017
Walker II WH, Borniger JC, Surbhi, Zalenski AA, Muscarella SL, Fitzgerald JA, Zhang N, Gaudier-Diaz MM, & DeVries AC. (2017) Mammary Tumors Induce Neuroinflammation, but Not Behavioral Deficits in Balb/C Mice. Scientific Reports, In press.
Borniger JC, Walker II WH, Gaudier-Diaz MM, Stegman C, Zhang N, Hollyfield JL, Nelson RJ, & DeVries AC. (2017). Time-of-day dictates the inflammatory response to cytotoxic chemotherapy. Scientific Reports. 7:41220. doi:10.1038/srep41220. PMID: 5259749
Walker II, W.H. , Borniger, J.C., Zalenski, A.A., Muscarella, S.L., Gaudier Diaz, M.M., Zhang, N., and DeVries, A.C. Tumor Progression and Inflammation: A Mouse Model of Breast Cancer. Society for Neuroscience Annual Meeting, San Diego CA, oral presentation, November 2016
Strahan JA, Walker II WH, Montgomery TR, and Forger N. G. (2016), Minocycline causes widespread cell death and increases microglial labeling in the neonatal mouse brain. Developmental Neurobiology. doi:10.1002/dneu.22457 PMID: 27706925
Borniger JC, Cissé YM, Gaudier-Diaz MM and Walker II WH (2016) Commentary: Anxiety- and Depression-like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice. Frontiers in Behavioral Neuroscience.10:130. doi: 10.3389/fnbeh.2016.00130 PMID: 27445039