Wesley Wang

Wesley Wang

Wesley Wang

Advisor: Jose Otero
He/Him/His

Wesley.Wang@osumc.edu

4170 Graves Hall
333 W 10th Avenue
Columbus, OH 43210

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Areas of Expertise

  • Gliomas
  • Machine Learning
  • Neuropathology

Education

  • BS in Neuroscience (2017), University of Washington
  • MS in Neuroscience (2021), The Ohio State University

Research

Glioblastomas (GBMs) are primary brain lesions with poor overall survival. One of the leading factors to this high mortality is the inevitable nature of cancer recurrence. In consequence, early detection of cancer return is critical to patient survival and monitored using serial magnetic resonance imaging (MRI) to detect areas of contrast enhancement indicatory of possible cancer return. However, similarly presenting pseudoprogression (psPD) complicates monitoring as such contrast enhancing lesions present identically under MRI. This paradigm complicates patient management clinically as psPD may be conservatively managed with monitoring and/or steroids while true cancer progression (PD) must be aggressively managed with surgery and treatment revision. In turn, histologic confirmation by neuropathology is critical in resolving novel MRI enhancements, but equally challenged in accurately classifying response as practical clinical guidelines do not exist. To examine this challenge, my project seeks to explore the underlying epidemiologic, transcriptomic and histologic features which characterize these responses using machine learning to derive novel understanding of disease mechanism and clinical guidelines.

Awards

2021 - Pathology Graduate Student of the Year, The Ohio State University

2021 - Best Poster Award- MSTP Division, The Ohio State University Wexner Medical Center Research Day

2021 - Society of ’67 Kinney Scholar, Association of Pathology Chairs

2021 - CCTS TL1 Fellowship NIH NCATS (2-year award)

2020 - Medical Student Award, American Society of Clinical Pathology

2020 - Best Poster Award – Basic Science Division, The Ohio State University Department of Pathology

2020 - TDAI/CCTS Research Award, The Ohio State University

2020 - University Fellowship, The Ohio State University Graduate School

2019 - AAN Medical Student Scholarship, American Academy of Neurology

2019 - Candy Apple Humanism Award, The Ohio State University

2018 - Neff Travel Award, Ohio State University

2018 - NIH MSTP T32 Fellowship, The Ohio State University

Publications

Sloan, E. A., Chiang, J., Villanueva-Meyer, J. E., Alexandrescu, S., Eschbacher, J. M., Wang, W., Mafra, M., Ud Din, N., Carr-Boyd, E., Watson, M., Punsoni, M., Oviedo, A., Gilani, A., Kleinschmidt-DeMasters, B. K., Coss, D. J., Lopes, M. B., Raffel, C., Berger, M. S., Chang, S. M., Reddy, A., Ramani B, Ferris SP, Lee JC, Hofmann JW, Cho SJ, Horvai AE, Pekmezci M, Tihan T, Bollen AW, Rodriguez FJ, Ellison DW, Perry A, Solomon, D. A. (2020). Intracranial mesenchymal tumor with FET-CREB fusion-A unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous histiocytoma-like neoplasms. Brain pathology, 31(4):e12918.

Wang, W., Alzate-Correa, D., Alves, M. J., Jones, M., Garcia, A. J., 3rd, Zhao, J., Czeisler, C. M., & Otero, J. J. (2021). Machine learning-based data analytic approaches for evaluating post-natal mouse respiratory physiological evolution. Respiratory physiology & neurobiology, 283:103558.

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