What exactly are the precise underlying mechanisms that result in motor neuron diseases (MNDs)? The Kolb lab is interested in addressing the molecular pathways, when changed, lead to MNDs. MNDs that the lab is particularly focused on studying include: Spinal Muscular Atrophy (SMA), Charcot-Marie-Tooth/distal Hereditary Motor Neuropathy type II (CMT/dHMNII) and Amyotrophic Lateral Sclerosis (ALS). My work has focused on investigating how mutations in small heat shock protein Beta-1 (HSPB1), an ubiquitously expressed protein with numerous functions, can lead to dHMNII.
2017 - American Neurological Academy Travel Award, ANA
Arnold WD, Sheth KA, Wier CG, Kissel JT, Burghes AH, and Kolb SJ. (2015) Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles. J Vis Exp. 2015 Sep 25;(103). doi: 10.3791/52899.
Wier, C.G., Knapp, A.R., Sheth, K.A., Heilman, P.L., Arnold, W.D. and Kolb, S.J. Longitudinal Mapping of Motor Unit Connectivity in Peripheral Nerve Repair. Abstract for poster presentation, 16th Annual Ohio State University Wexner Medical Center Trainee Research Day Columbus, OH April 2017 and Life Sciences Interdisciplinary Graduate Programs
Symposium, Columbus, OH, May 2017.
“Mapping discrepant behavioral and electrophysiological recovery following peripheral nerve injury” at American Academy of Neurology conference in Vancouver, BC, Canada, April 2016.
“Mapping discrepant behavioral and electrophysiological recovery following peripheral nerve injury” at IGP Symposium in Columbus, OH, May 2016.