Wenyuan (Ren) Yin

Wenyuan (Ren) Yin

Wenyuan (Ren) Yin

Co-Advisors: Jonathan Godbout and John Sheridan
She/Her/Hers

Wenyuan.Yin@osumc.edu

(614) 366-3496

247 Institute for Behavioral Medicine Research
460 Medical Center Drive
Columbus, OH 43210

Google Map

Areas of Expertise

  • Behavioral Neuroscience
  • Neurotrauma, Neurological Disorders, and Gene/Clinical Thera
  • Stress and Neuroimmunology

Education

  • BA in Biology (2016), University of Louisville

Research

I am interested in understanding the role of bidirectional immune-brain communication in the development of anxiety and depression after psychosocial stress. My lab uses a mouse model of chronic social defeat in order to investigate neuroimmune responses following stress. We have previously shown that bone marrow-derived monocytes from the periphery play a crucial role in the development of anxiety-like behavior following stress, and communicate with the CNS to propagate inflammatory signaling. I am particularly interested in signaling between monocytes, endothelial cells at the blood-brain barrier, and microglia, and how those interactions affect behavior.

Awards

2021 - Fellow, NIH NRSA F30MH125524

2020 - Training Program in Neuroimmunology T32 Fellow (1-year award)

2020 - First Place Poster Award in Biology, The Ohio State University Edward F. Hayes Graduate Research Forum

2020 - Inter-professional Council Professional Development Award

2019 - Service Award, The Ohio State University Department of Neuroscience

2018 - University Fellowship, The Ohio State University Graduate School

Publications

Gomez-Gutierrez JG, Bhutiani N, McNally MW, Chuong P, Yin W, Jones MA, Zeiderman MR, Grizzle WE, McNally LR. (2021) The neutral red assay can be used to evaluate accurately cell viability during autophagy or in an acidic microenvironment in vitro. Biotech Histochem. 96(4):302-310. doi: 10.1080/10520295.2020.1802065. Epub 2020 Aug 3.

Thomas A, Samykutty A, Gomez-Gutierrez JG, Yin W, Egger ME, McNally M, Chuong P, MacCuaig WM, Albeituni S, Zeiderman M, Li M, Edil BH, Grizzle WE, McMasters KM, McNally LR. (2021) Actively Targeted Liposomal Delivery of Echinomycin Induces Autophagy Mediated Death in Chemoresistant Pancreatic Cancer in vivo. Cancers. 12(8):2279. doi: 10.3390/cancers12082279.

Witcher KG, Yin W, Sheridan JF, Godbout JP. (2019) Reply to Microglia, Monocytes, and the Recurrence of Anxiety in Stress-Sensitized Mice. Biol Psychiatry. 85(12):e69-e70. doi: 10.1016/j.biopsych.2019.01.026. Epub 2019 Mar 8.

Yin W, Gallagher NR, Sawicki CM, McKim DB, Godbout JP, Sheridan JF. (2019) Repeated Social Defeat in Female Mice Induces Anxiety-Like Behavior Associated with Enhanced Myelopoiesis and Increased Monocyte Accumulation in the Brain. Brain, Behavior, and Immunity. 78:131-142. doi: 10.1016/j.bbi.2019.01.015. Epub 2019 Jan 23.

McKim DB, Yin W, Wang Y, Cole SW, Godbout JP, Sheridan JF. (2018) Social Stress Mobilizes Hematopoietic Stem Cells to Establish Persistent Splenic Myelopoiesis. Cell Rep. 25(9):2552-2562.e3. doi: 10.1016/j.celrep.2018.10.102.

Weber MD, McKim DB, Niraula A, Witcher KG, Yin W, Sobol CG, Wang Y, Sawicki CM, Sheridan JF, Godbout JP. (2018) The Influence of Microglial Elimination and Repopulation on Stress-Sensitization Induced by Repeated Social Defeat. Biol Psychiatry. 85(8):667-678. doi: 10.1016/j.biopsych.2018.10.009. Epub 2018 Oct 25.

People Filters: