Neurotrauma, Neurological Disorders, and Gene/Clinical Therapies

D. Michele Basso, EdD, PT
Neural substrates of functional recovery after spinal cord injury; mechanisms and efficacy of therapeutic intervention on muscle, peripheral nerve and spinal cord after traumatic spinal cord injury.

Christine Beattie, PhD
Molecular mechanisms controlling vertebrate axon guidance during development and disease using zebrafish as a model system.

Lei Cao, PhD
Use multidisciplinary approaches to further define a novel brain-fat axis (hypothalamic-sympathoneural-adipocyte axis), identify molecular mediators, and develop both genetic and pharmacological approaches to combat obesity, metabolic syndromes, and cancer.

H. Francis Farhadi, MD, PhD
Developing and validating small animal models of central and peripheral nervous system injury wherein the potential of stem cell implantation to enhance functional recovery can be tested.

Liang GuoPhD
Integrate advances in electronics, micro/nanofabrication, tissue engineering, synthetic biology, biomaterials, and neural engineering into the engineering of advanced neural interfacing technologies for neuroscience and neural prosthetics.

Andrew Hartwick, PhD
Physiology of melanopsin-containing retinal ganglion cells; Mechanisms underlying photophobia in TBI patients; Intraocular pressure rhythms and glaucoma.

Jaime Imitola, MD
Identify and validate genes that mediate the responses of neural stem cells (NSCs) to CNS injury in multiple sclerosis and brain cancer in the so-called injury-induced stem cell niches.

Brian Kaspar, PhD
Mechanism(s) of neurodegeneration in Amyotrophic Lateral Sclerosis (ALS) and the design and utilization of novel therapies to combat this debilitating, lethal disease.

Stephen Kolb, PhD
Understand the molecular pathogenesis of motor neuron diseases and the hereditary neuropathies.

Jessica Lerch, PhD
Gene expression regulation in the context of axon regeneration and neuropathic pain development.

Paul Martin, PhD
Understanding the role of glycoyslation in synapse formation and muscular dystrophy.

Dana McTigue, PhD
Spinal cord injury and recovery of function, demyelination and remyelination, oligodendrocyte progenitor function, transplantation.

W. Jerry Mysiw, MD
Improving outcomes after traumatic brain injury and spinal cord injury. 

Jose Otero, MD, PhD
Elucidate the mechanisms of developmental and neoplastic disorders of the central nervous system.  

Phillip Popovich, PhD
Neuroimmunology of spinal cord injury, immunological influences on neuronal degeneration and regeneration, neuroendocrine influences (e.g., stress/HPA axis activation) on inflammatory mediated injury/repair of the CNS.

Leah Pyter, PhD
Determine the immune/inflammatory mechanisms by which cancer and stress delay the healing of wounds caused by cancer treatments (surgery, radiation, etc.).

Michael Racke, MD
Understanding how inflammation gets established in the central nervous system and developing novel therapeutics by studying the animal model experimental autoimmune encephalomyelitis.

Ali Rezai, MD
Novel clinical application of neuromodulation for treatment of neurological and psychiatric disorders.

Jan Schwab, MD, PhD
Better understand and treat the maladaptive immune response after spinal cord injury.

Yingjie Shen, PhD
Understand the molecular and cellular mechanisms of CNS injuries and degenerative diseases. 

Zachary Weil, PhD
How traumatic brain injuries predispose individuals to subsequent injuries and long term disability and specifically how changes in brain energy metabolism are dysregulated by injury.